The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential
class of metabolites found throughout all kingdoms of life. In this comprehensive review, we …

Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …

Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees
with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. Here we …

“Sola dosis facit venenum.” These words of Paracelsus,“the dose makes the poison”, can
lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance …

Many genetic risk factors for Parkinson's disease have lipid-related functions and lipid-
modulating drugs such as statins may be protective against Parkinson's disease. Moreover …

Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions
between environmental and genetic factors. Metabolomics can shed light on alterations in …

The exposome is the cumulative measure of environmental influences and associated
biological responses throughout the lifespan, including exposures from the environment …

The pathogenesis of Parkinson's disease (PD) remains to be elucidated. Metabolomic
analysis has the potential to identify biochemical pathways and metabolic profiles that are …