Seleno-compounds in garlic and onion
I Arnault, J Auger - Journal of Chromatography A, 2006 - Elsevier
Garlic (Allium sativum) and onion (Allium cepa) are widely known for their biological
properties but are far from having revealed all of their secrets even if the compounds …
properties but are far from having revealed all of their secrets even if the compounds …
Chlorinated methanes and liver injury: highlights of the past 50 years
GL Plaa - Annual review of pharmacology and toxicology, 2000 - annualreviews.org
The chlorinated methanes, particularly carbon tetrachloride and chloroform, are classic
models of liver injury and have developed into important experimental hepatoxicants over …
models of liver injury and have developed into important experimental hepatoxicants over …
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
BK Gunawan, ZX Liu, D Han, N Hanawa, WA Gaarde… - Gastroenterology, 2006 - Elsevier
Background & Aims: In searching for effects of acetaminophen (APAP) on hepatocytes
downstream of its metabolism that may participate in hepatotoxicity, we examined the role of …
downstream of its metabolism that may participate in hepatotoxicity, we examined the role of …
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
H Nakagawa, S Maeda, Y Hikiba, T Ohmae, W Shibata… - Gastroenterology, 2008 - Elsevier
Background & Aims: Acetaminophen (APAP) overdose is the most frequent cause of drug-
induced liver failure. C-jun N-terminal kinase (JNK) is thought to play a central role in APAP …
induced liver failure. C-jun N-terminal kinase (JNK) is thought to play a central role in APAP …
Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation
X Zhang, G Kuang, J Wan, R Jiang, L Ma… - International …, 2020 - Elsevier
Salidroside (Sal), a natural phenolic compound isolated from Rhodiola sachalinensis, has
been utilized as anti-inflammatory and antioxidant for centuries, however, its effects against …
been utilized as anti-inflammatory and antioxidant for centuries, however, its effects against …
Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes
RC Zangar, JM Benson, VL Burnett… - Chemico-biological …, 2000 - Elsevier
We examined which human CYP450 forms contribute to carbon tetrachloride (CCl4)
bioactivation using hepatic microsomes, heterologously expressed enzymes, inhibitory …
bioactivation using hepatic microsomes, heterologously expressed enzymes, inhibitory …
The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride.
T Fukao, T Hosono, S Misawa, T Seki, T Ariga - Food and Chemical …, 2004 - Elsevier
Allyl sulfides, eg, diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS),
are principal constituents of garlic oil. In the present study, we investigated the in vivo effect …
are principal constituents of garlic oil. In the present study, we investigated the in vivo effect …
Modulation of phase II enzymes by organosulfur compounds from allium vegetables in rat tissues
D Guyonnet, MH Siess, AM Le Bon… - Toxicology and applied …, 1999 - Elsevier
The naturally occurring organosulfur compounds (OSCs) diallyl sulfide (DAS), diallyl
disulfide (DADS), dipropyl sulfide (DPS), and dipropyl disulfide (DPDS) were studied with …
disulfide (DADS), dipropyl sulfide (DPS), and dipropyl disulfide (DPDS) were studied with …
Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction
D Guyonnet, C Belloir, M Suschetet, MH Siess… - … /Genetic Toxicology and …, 2001 - Elsevier
In a previous study, we showed that naturally occurring organosulfur compounds (OSCs)
from garlic and onion modulated the activation of carcinogen via the alteration of …
from garlic and onion modulated the activation of carcinogen via the alteration of …
The protective action of thymol against carbon tetrachloride hepatotoxicity in mice
The protective action of thymol (paramethyl-isopropyl-phenol) was investigated against
carbon tetrachloride (CCl4)-induced hepatotoxicity in male Swiss albino mice. The CCl4at a …
carbon tetrachloride (CCl4)-induced hepatotoxicity in male Swiss albino mice. The CCl4at a …