In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

The endoplasmic-reticulum (ER) stress response constitutes a cellular process that is
triggered by a variety of conditions that disturb folding of proteins in the ER. Eukaryotic cells …

Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …

SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

The replication of coronavirus, a family of important animal and human pathogens, is closely
associated with the cellular membrane compartments, especially the endoplasmic reticulum …

Recent evidence suggests that dysfunctional type II alveolar epithelial cells (AECs)
contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Based on the …

The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is reported to cause
apoptosis of infected cells and several of its proteins including the 3a accessory protein, are …

Viral infection induces endoplasmic reticulum (ER) stress and interferon responses. While
viral double-stranded RNA intermediates trigger interferon responses, viral polypeptides …