Chagas disease drug discovery: toward a new era
E Chatelain - Journal of biomolecular screening, 2015 - journals.sagepub.com
American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …
cruzi parasite. Endemic in Latin America where it is the major cause of death from …
Diagnosis and management of Chagas disease and cardiomyopathy
AL Ribeiro, MP Nunes, MM Teixeira… - Nature Reviews …, 2012 - nature.com
Chagas cardiomyopathy is the most severe and life-threatening manifestation of human
Chagas disease—a'neglected'tropical disease caused by the protozoan parasite …
Chagas disease—a'neglected'tropical disease caused by the protozoan parasite …
Pathogen diversity, immunity, and the fate of infections: lessons learned from Trypanosoma cruzi human–host interactions
The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …
infection with different pathogen strains. In this Review, we explore the interactions between …
Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and …
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …
and development for Chagas disease, a chronic infection caused by the genetically …
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging
AF Francisco, MD Lewis, S Jayawardhana… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The antifungal drug posaconazole has shown significant activity against Trypanosoma cruzi
in vitro and in experimental murine models. Despite this, in a recent clinical trial it displayed …
in vitro and in experimental murine models. Despite this, in a recent clinical trial it displayed …
Translational challenges of animal models in Chagas disease drug development: a review
E Chatelain, N Konar - Drug design, development and therapy, 2015 - Taylor & Francis
Chagas disease, or American trypanosomiasis, caused by Trypanosoma cruzi parasite
infection is endemic in Latin America and presents an increasing clinical challenge due to …
infection is endemic in Latin America and presents an increasing clinical challenge due to …
Current status of Chagas disease chemotherapy
PMM Guedes, GK Silva, FRS Gutierrez… - Expert review of anti …, 2011 - Taylor & Francis
Chagas disease affects 7.7 million people and 28 million people are at risk of acquiring the
disease in 15 endemic countries of Latin America. Benznidazole and nifurtimox are drugs …
disease in 15 endemic countries of Latin America. Benznidazole and nifurtimox are drugs …
Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective
LG Ferreira, AD Andricopulo - Drug Discovery Today, 2016 - Elsevier
Highlights•Neglected tropical diseases affect approximately one billion people
worldwide.•Most of the available drugs have limited efficacy and cause serious adverse …
worldwide.•Most of the available drugs have limited efficacy and cause serious adverse …
Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis
G I. Lepesheva, M R. Waterman - Current topics in medicinal …, 2011 - benthamdirect.com
Pathogenic protozoa threaten lives of several hundred million people throughout the world
and are responsible for large numbers of deaths globally. The parasites are transmitted to …
and are responsible for large numbers of deaths globally. The parasites are transmitted to …
A New Experimental Model for Assessing Drug Efficacy against Trypanosoma cruzi Infection Based on Highly Sensitive In Vivo Imaging
The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, one of the
world's major neglected infections. Although development of improved antiparasitic drugs is …
world's major neglected infections. Although development of improved antiparasitic drugs is …