Monocarboxylate transporters in the central nervous system: distribution, regulation and function

K Pierre, L Pellerin - Journal of neurochemistry, 2005 - Wiley Online Library
Monocarboxylate transporters (MCTs) are proton‐linked membrane carriers involved in the
transport of monocarboxylates such as lactate, pyruvate, as well as ketone bodies. They …

Neuroenergetics: calling upon astrocytes to satisfy hungry neurons

L Pellerin, PJ Magistretti - The Neuroscientist, 2004 - journals.sagepub.com
Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells
and its full oxidation provides all the necessary energy to support brain function. Recent data …

[HTML][HTML] The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide

T Soucek, R Cumming, R Dargusch, P Maher… - Neuron, 2003 - cell.com
It is frequently argued that both amyloid beta (Aβ) and oxidative stress are involved in the
pathogenesis of Alzheimer's disease (AD). We show here that clonal nerve cell lines and …

How astrocytes feed hungry neurons

L Pellerin - Molecular neurobiology, 2005 - Springer
For years glucose was thought to constitute the sole energy substrate for neurons; it was
believed to be directly provided to neurons via the extracellular space by the cerebral …

The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos

J Fu, YXR Tan, Z Gong, S Bae - Ecotoxicology and environmental safety, 2020 - Elsevier
The omnipresence of antimicrobial triclosan (TCS) and by-products in aquatic environments
is a threat to aquatic organisms. Traditionally, the adverse effects of TCS and its by-products …

Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics

TM Bliss, M Ip, E Cheng, M Minami… - Journal of …, 2004 - Soc Neuroscience
Increasing evidence suggests that glutamate activates the generation of lactate from glucose
in astrocytes; this lactate is shuttled to neurons that use it as a preferential energy source …

Comparison of transitional vs surgical menopause on monoamine and amino acid levels in the rat brain

T Long, JK Yao, J Li, ZZ Kirshner, D Nelson… - Molecular and cellular …, 2018 - Elsevier
Loss of ovarian function has important effects on neurotransmitter production and release
with corresponding effects on cognitive performance. To date, there has been little direct …

De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar …

B Pardo, L Contreras, J Satrústegui - Frontiers in endocrinology, 2013 - frontiersin.org
In brain, the glutamate-glutamine and the glutamate-glutamine-GABA cycles are essential
for efficient glutamatergic and GABAergic neurotransmission. The interactions between …

Aggregating neural cell cultures

P Honegger - Current protocols in toxicology, 2003 - Wiley Online Library
Abstract Aggregating Neural Cell Cultures (Paul Honegger, University of Lausanne,
Lausanne, Switzerland). When freshly dissociated embryonic tissues are kept under …

Metabolic and regulatory roles of leucine in neural cells

R Murín, B Hamprecht - Neurochemical research, 2008 - Springer
Dietary leucine transported into the brain parenchyma serves several functions. Most
prominent is the role of leucine as a metabolic precursor of fuel molecules, α …