The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

Breast cancer is the most prevalent cancer among women and the leading cause of cancer-
related deaths in this population. Recent advances in Immunotherapy, or combined …

Each biopharmaceutical research and new drug development investigation is targeted at
discovering novel and potent medications for managing specific ailments. Thus, to discover …

Zearalenone is an estrogenic mycotoxin which is a common food contaminant and has been
implicated in increasing the incidence of carcinogenesis and other reproductive health …

Abstract A series of 1-(4-chlorobenzhydryl) piperazine derivatives 3–10 were synthesized
and characterized both spectroscopically and structurally to investigate their antiproliferative …

Leishmaniasis is a widespread parasitic disease and is one of the major public health
concerns in developing countries. Many drugs have been identified for leishmania as …

Abstract 4-((4-(1-benzyl-2-methyl-4-nitro-1H-imidazole-5-yl) piperazine-1-yl) methyl)-1-
substituted-1H-1, 2, 3-triazole motifs are designed and synthesized via click chemistry. The …

Trypanosoma cruzi is a protozoan transmitted by the insect Triatoma infestans, popularly
known as kissing bug. This protozoan causes the Chagas disease, a Neglected Tropical …

Introduction: Cancer is a vast group of diseases comprising abnormal cells that multiply and
grow uncontrollably, and it is one of the top causes of death globally. Several types of …

Breast cancer is the main cancer type with more than 2.2 million cases in 2020, and is the
principal cause of death in women; with 685000 deaths in 2020 worldwide. The estrogen …