Next-generation sequencing has revolutionized clinical diagnostic testing. Yet, for a
substantial proportion of patients, sequence information restricted to exons and exon–intron …

In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of
the prominent roles is to regulate gene expression. A vast number of circular RNAs …

Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …

Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to
achieve their diverse functions. To identify these contacts, we developed a method based on …

The expansion of introns within mammalian genomes poses a challenge for the production
of full-length messenger RNAs (mRNAs), with increasing evidence that these long AT-rich …

Transcription, translation and subsequent protein modification represent the transfer of
genetic information from the archival copy of DNA to the short-lived messenger RNA, usually …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …