Intense investigation continues on the pathobiology of stent thrombosis (ST) because of its
morbidity and mortality. Because little advance has been made in outcomes following ST …

Phenoconversion is a phenomenon that converts genotypic extensive metabolizers (EM s)
into phenotypic poor metabolizers (PM s) of drugs, thereby modifying their clinical response …

This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy
(ESGE). It addresses the diagnosis and management of nonvariceal upper gastrointestinal …

Multidrug therapy increases the risk for drug–drug interactions. Clopidogrel, a prodrug,
requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active …

Background—Discordant results have been reported on the effects of concomitant use of
proton pump inhibitors (PPIs) and dual antiplatelet therapy (DAPT) for cardiovascular …

Background Observational studies evaluating the possible interaction between proton pump
inhibitors (PPI s) and clopidogrel have shown mixed results. We conducted a systematic …

Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we
combined a literature discovery approach with analysis of a large electronic medical record …

Background Data from pharmacokinetic and pharmacodynamic studies indicate that the
adverse clopidogrel–proton pump inhibitor (PPI) interaction may vary between PPIs, with …

Advancements in genomics and personalized medicine not only effect healthcare delivery
from patient and provider standpoints, but also reshape biomedical discovery. We are in the …

BACKGROUND: Uncertainty regarding clopidogrel effectiveness attenuation because of a
drug-drug interaction with proton pump inhibitors (PPI) has led to conflicting guidelines on …