ABC transporters: a riddle wrapped in a mystery inside an enigma
ATP-binding cassette (ABC) transporters form one of the largest and most ancient of protein
families. ABC transporters couple hydrolysis of ATP to vectorial translocation of diverse …
families. ABC transporters couple hydrolysis of ATP to vectorial translocation of diverse …
The molecular and physiological roles of ABCC6: more than meets the eye
O Le Saux, L Martin, Z Aherrahrou, G Leftheriotis… - Frontiers in …, 2012 - frontiersin.org
Abnormal mineralization occurs in the context of several common conditions, including
advanced age, diabetes, hypercholesterolemia, chronic renal failure, and certain genetic …
advanced age, diabetes, hypercholesterolemia, chronic renal failure, and certain genetic …
On the origin of large flexibility of P-glycoprotein in the inward-facing state
PC Wen, B Verhalen, S Wilkens, HS Mchaourab… - Journal of Biological …, 2013 - ASBMB
P-glycoprotein (Pgp) is one of the most biomedically relevant transporters in the ATP binding
cassette (ABC) superfamily due to its involvement in developing multidrug resistance in …
cassette (ABC) superfamily due to its involvement in developing multidrug resistance in …
Homology modeling of the human P-glycoprotein (ABCB1) and insights into ligand binding through molecular docking studies
L Mora Lagares, N Minovski… - International journal of …, 2020 - mdpi.com
The ABCB1 transporter also known as P-glycoprotein (P-gp) is a transmembrane protein
belonging to the ATP binding cassette super-family of transporters; it is a xenobiotic efflux …
belonging to the ATP binding cassette super-family of transporters; it is a xenobiotic efflux …
Multidrug Transport by the ABC Transporter Sav1866 from Staphylococcus aureus
S Velamakanni, Y Yao, DAP Gutmann… - Biochemistry, 2008 - ACS Publications
Sav1866 is an ATP-binding cassette (ABC) protein from the pathogen Staphylococcus
aureus and is a homologue of bacterial and human multidrug ABC transporters. Recently …
aureus and is a homologue of bacterial and human multidrug ABC transporters. Recently …
Overexpression of ABCB1 transporter confers resistance to mTOR inhibitor WYE-354 in cancer cells
The overexpressing ABCB1 transporter is one of the key factors leading to multidrug
resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome …
resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome …
Mutational analysis of ABC proteins
TW Loo, DM Clarke - Archives of biochemistry and biophysics, 2008 - Elsevier
The 49 human members of the ATP-binding cassette (ABC) family of proteins are involved in
a wide range of activities such as active transport of compounds across membranes …
a wide range of activities such as active transport of compounds across membranes …
Molecular models of human P-glycoprotein in two different catalytic states
JP Becker, G Depret, F Van Bambeke, PM Tulkens… - BMC Structural …, 2009 - Springer
Background P-glycoprotein belongs to the family of ATP-binding cassette proteins which
hydrolyze ATP to catalyse the translocation of their substrates through membranes. This …
hydrolyze ATP to catalyse the translocation of their substrates through membranes. This …
Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in …
Abstract Background The Multidrug Resistance Protein ABCC11/MRP8 is expressed in
physiological barriers and tumor breast tissues in which it secretes various substrates …
physiological barriers and tumor breast tissues in which it secretes various substrates …
Multidrug efflux pumps: The structures of prokaryotic ATP‐binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P …
One of the Holy Grails of ATP‐binding cassette transporter research is a structural
understanding of drug binding and transport in a eukaryotic multidrug resistance pump …
understanding of drug binding and transport in a eukaryotic multidrug resistance pump …