Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …
an overwhelming health, social, economic, and political problem to nations. Unless a new …
β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
M Bartolini, C Bertucci, V Cavrini, V Andrisano - Biochemical pharmacology, 2003 - Elsevier
The aggregation of β-amyloid (1–40)(Aβ) induced by human recombinant
acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by …
acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by …
Xanthone derivatives: new insights in biological activities
MMM Pinto, ME Sousa… - Current medicinal …, 2005 - ingentaconnect.com
Xanthones or 9H-xanthen-9-ones (dibenzo-γ-pirone) comprise an important class of
oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological …
oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological …
Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimer s Disease
DM Torrero - Frontiers in Medicinal Chemistry: Volume 7, 2015 - benthamdirect.com
The therapeutic arsenal for the treatment of Alzheimer s disease (AD) remains confined to a
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
A Castro, A Martinez - Current pharmaceutical design, 2006 - ingentaconnect.com
Although the hallmarks of neurodegeneration in Alzheimer's brains are well known, one of
the current difficulties is related to the lack of solid evidence about the ultimate factors that …
the current difficulties is related to the lack of solid evidence about the ultimate factors that …
Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, β amyloid aggregation, and Aβ neurotoxicity
S Rizzo, C Rivière, L Piazzi, A Bisi… - Journal of medicinal …, 2008 - ACS Publications
The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget
strategies to combat causes and symptoms. We therefore designed, synthesized, and tested …
strategies to combat causes and symptoms. We therefore designed, synthesized, and tested …
Synthesis of xanthones: an overview
ME Sousa, MMM Pinto - Current medicinal chemistry, 2005 - ingentaconnect.com
Among the known synthetic routes to obtain xanthones, the Grover, Shah, and Shah
reaction, the cyclodehydration of 2, 2'-dihydroxybenzophenones and electrophilic …
reaction, the cyclodehydration of 2, 2'-dihydroxybenzophenones and electrophilic …
Hybrids: a new paradigm to treat Alzheimer's disease
Alzheimer's disease (AD) is a complex neurodegenerative condition with several target
proteins contributing to its etiology. With 35.6 million cases worldwide documented in 2011 …
proteins contributing to its etiology. With 35.6 million cases worldwide documented in 2011 …