Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs
R Akkari, JC Burbiel, J Hockemeyer… - Current topics in …, 2006 - ingentaconnect.com
Adenosine receptors belong to the family of G protein-coupled receptors. Four distinct
subtypes are known, termed A1, A2A, A2B and A3. Adenosine is an important signaling …
subtypes are known, termed A1, A2A, A2B and A3. Adenosine is an important signaling …
Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates
RV Kalla, J Zablocki - Purinergic signalling, 2009 - Springer
The selective, high affinity A 2B adenosine receptor (AdoR) antagonists that were
synthesized by several research groups should aid in determining the role of the A 2B AdoR …
synthesized by several research groups should aid in determining the role of the A 2B AdoR …
Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV
AB Kanstrup, LB Christiansen, JM Lundbeck… - US Patent …, 2007 - Google Patents
US7235538B2 - Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV -
Google Patents US7235538B2 - Heterocyclic compounds, which are inhibitors of the enzyme …
Google Patents US7235538B2 - Heterocyclic compounds, which are inhibitors of the enzyme …
Derivatives of 8-substituted xanthines
G Wang, JM Rieger, RD Thompson - US Patent 7,579,348, 2009 - Google Patents
US7579348B2 - Derivatives of 8-substituted xanthines - Google Patents US7579348B2 -
Derivatives of 8-substituted xanthines - Google Patents Derivatives of 8-substituted xanthines …
Derivatives of 8-substituted xanthines - Google Patents Derivatives of 8-substituted xanthines …
Novel 1,3-Disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) Xanthines: High Affinity and Selective A2B Adenosine Receptor Antagonists
Adenosine has been suggested to induce bronchial hyperresponsiveness in asthmatics,
which is believed to be an A2B adenosine receptor (AdoR) mediated pathway. We …
which is believed to be an A2B adenosine receptor (AdoR) mediated pathway. We …
A2B adenosine receptor antagonists
BACKGROUND Adenosine is a naturally occurring nucleoside, which exerts its biological
effects by interacting with a family of adenosine receptors known as A1, A2, A2, and As, all of …
effects by interacting with a family of adenosine receptors known as A1, A2, A2, and As, all of …
1-, 3-and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor
A Stefanachi, JM Brea, MI Cadavid, NB Centeno… - Bioorganic & medicinal …, 2008 - Elsevier
A large series of piperazin-, piperidin-and tetrahydroisoquinolinamides of 4-(1, 3-dialkyl-9-
deazaxanthin-8-yl) phenoxyacetic acid were prepared through conventional or multiple …
deazaxanthin-8-yl) phenoxyacetic acid were prepared through conventional or multiple …
Method of treating hepatic disease using A2B adenosine receptor antagonists
D Zeng, H Zhong, L Belardinelli - US Patent 7,795,268, 2010 - Google Patents
US7795268B2 - Method of treating hepatic disease using A2B adenosine receptor
antagonists - Google Patents US7795268B2 - Method of treating hepatic disease using A2B …
antagonists - Google Patents US7795268B2 - Method of treating hepatic disease using A2B …
Substituted fused pyrimidine compounds
The present invention discloses substituted fused pyrimidine compounds of formula (I), their
tautomers, polymorphs, Ste reoisomers, Solvates, pharmaceutically acceptable salts, or …
tautomers, polymorphs, Ste reoisomers, Solvates, pharmaceutically acceptable salts, or …
Methods and Compositions for Increasing Patent Tolerability During Myocardial Imaging Methods
H Lieu, B Blackburn, L Belardinelli - US Patent App. 11/848,743, 2008 - Google Patents
The following are aspects of this invention: 0009. A pharmaceutical composition comprising
caffeine 50 mg to 1000 mg caffeine, at least 10 ug of at least one partial A receptor agonist …
caffeine 50 mg to 1000 mg caffeine, at least 10 ug of at least one partial A receptor agonist …