Harnessing AlphaFold to reveal hERG channel conformational state secrets
To design safe, selective, and effective new therapies, there must be a deep understanding
of the structure and function of the drug target. One of the most difficult problems to solve has …
of the structure and function of the drug target. One of the most difficult problems to solve has …
Selectivity filter mutations shift ion permeation mechanism in potassium channels
A Mironenko, BL de Groot, W Kopec - bioRxiv, 2023 - biorxiv.org
Potassium (K+) channels combine high conductance with high ion selectivity. To explain this
efficiency, two molecular mechanisms have been proposed. The 'direct knock …
efficiency, two molecular mechanisms have been proposed. The 'direct knock …