Arterial stiffness is a major independent risk factor for cardiovascular complications causing
isolated systolic hypertension and increased pulse pressure in the microvasculature of …

Elevated expression of the multifunctional cytokine transforming growth factor β1 (TGF-β1) is
causatively linked to kidney fibrosis progression initiated by diabetic, hypertensive …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

The joint pollution of microplastics (MPs) and di-(2-ethylhexyl) phthalic acid (DEHP) often
occurs, and consequently poses a serious threat to human and animal health, which has …

Diabetes is the most frequent cause of kidney disease that progresses to end-stage renal
disease worldwide, and diabetic kidney disease is significantly related to unfavorable …

Small molecule inhibitors of GTPases are increasingly considered for the treatment of
multiple human pathologies. The GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1) …

Abstract p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While
involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the …

Despite their emerging relevance to fully understand disease pathogenesis, we have as yet
a poor understanding as to how biomechanical signals are integrated with specific …

The advancement of new therapies, including targeted therapies and immunotherapies, has
improved the survival of non-small-cell lung cancer (NSCLC) patients in the last decade …

Multiple mechanisms are involved in kidney damage, among which the role of epigenetic
modifications in the occurrence and development of kidney diseases is constantly being …