The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Cultivated meat scale-up and industrial production will require multiple stable cell lines from
different species to recreate the organoleptic and nutritional properties of meat from …

Partial pluripotent reprogramming can reverse features of aging in mammalian cells, but the
impact on somatic identity and the necessity of individual reprogramming factors remain …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging
phenotypes and age-related diseases. Here, we report that impaired mitochondrial function …

Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and
the diseases it causes, with transient expression of nuclear reprogramming factors recently …

We investigate the age-related metabolic changes that occur in aged and rejuvenated
myoblasts using in vitro and in vivo models of aging. Metabolic and signaling experiments …

ABSTRACT 'Age reprogramming'refers to the process by which the molecular and cellular
pathways of a cell that are subject to age-related decline are rejuvenated without passage …

Cellular senescence leads to the depletion of myogenic progenitors and decreased
regenerative capacity. We show that the small molecule 2, 6‐disubstituted purine, reversine …

Metabolic and transcriptional reprogramming are crucial hallmarks of carcinogenesis that
present exploitable vulnerabilities for the development of targeted anticancer therapies …