The facts that many proteins with crucial biological functions do not have unique structures
and that many biological processes are compartmentalized into the liquid-like biomolecular …

The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …

Recent efforts to identify RNA binding proteins in various organisms and cellular contexts
have yielded a large collection of proteins that are capable of RNA binding in the absence of …

Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis,
therapy resistance and metastasis. Radiobiological hypoxia (< 0.1% O2) is one of the few …

The biological implications of R-loops are increasingly receiving attention in plant biology.
Compared with recent progresses in humans, the studies of R-loops in plants are lagging …

Transcription elongation, especially RNA polymerase II (Pol II) pause-release, is less
studied than transcription initiation in regulating gene expression during meiosis. It is also …

Complex pathways involving the DNA damage response (DDR) contend with cell-intrinsic
and-extrinsic sources of DNA damage. DDR mis-regulation results in genome instability that …

Background Many long non-coding RNAs, known to be involved in transcriptional
regulation, are enriched in the nucleus and interact with chromatin. However, their …

A non-canonical DNA/RNA structure, G-quadruplex (G4), is a unique structure formed by two
or more guanine quartets, which associate through Hoogsteen hydrogen bonding leading to …