Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and …

A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

Klebsiella oxytoca is actually a complex of nine species—Klebsiella grimontii, Klebsiella
huaxiensis, Klebsiella michiganensis, K. oxytoca, Klebsiella pasteurii, Klebsiella …

Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) strains are a major
threat to global health. The development of effective control measures requires more …

Infections caused by carbapenemase-producing enterobacteria (CPE) are a major concern
in clinical settings worldwide. Two fundamentally different processes shape the …

Molecular and genomic surveillance systems for bacterial pathogens currently rely on
tracking clonally evolving lineages. By contrast, plasmids are usually excluded or analyzed …

Importance The development of antibiotics is considered among the most important
advances of modern science. Antibiotics have saved millions of lives. However …

Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public
health problem. While resistance can occur across a broad range of Kp clones, a small …