ceRNA in cancer: possible functions and clinical implications

X Qi, DH Zhang, N Wu, JH Xiao, X Wang… - Journal of medical …, 2015 - jmg.bmj.com
Competing endogenous RNAs (ceRNAs) are transcripts that can regulate each other at post-
transcription level by competing for shared miRNAs. CeRNA networks link the function of …

The evolution of gene regulation by transcription factors and microRNAs

K Chen, N Rajewsky - Nature Reviews Genetics, 2007 - nature.com
Abstract Changes in the patterns of gene expression are widely believed to underlie many of
the phenotypic differences within and between species. Although much emphasis has been …

MiRNAs: biology, biogenesis, their web-based tools, and databases

M Tafrihi, E Hasheminasab - Microrna, 2019 - ingentaconnect.com
Introduction: MicroRNAs (miRNAs), which are evolutionarily conserved, and endogenous
non-coding RNAs, participate in the post-transcriptional regulation of eukaryotic genes. The …

Strategies for silencing human disease using RNA interference

DH Kim, JJ Rossi - Nature Reviews Genetics, 2007 - nature.com
Since the first description of RNA interference (RNAi) in animals less than a decade ago,
there has been rapid progress towards its use as a therapeutic modality against human …

The evolution of RNAi as a defence against viruses and transposable elements

DJ Obbard, KHJ Gordon, AH Buck… - … Transactions of the …, 2009 - royalsocietypublishing.org
RNA interference (RNAi) is an important defence against viruses and transposable elements
(TEs). RNAi not only protects against viruses by degrading viral RNA, but hosts and viruses …

microRNAs and the immune response

MA Lindsay - Trends in immunology, 2008 - cell.com
microRNA (miRNA)-mediated RNA interference has been identified as a novel mechanism
that regulates protein expression at the translational level. Recent publications have …

Critical role of microRNA-21 in the pathogenesis of liver diseases

T Zhang, Z Yang, P Kusumanchi, S Han… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As
one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed …

Micromanagement of the immune system by microRNAs

HF Lodish, B Zhou, G Liu, CZ Chen - Nature Reviews Immunology, 2008 - nature.com
MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved small non-coding
RNAs that are thought to control gene expression by targeting mRNAs for degradation or …

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system

M Wakiyama, K Takimoto, O Ohara… - Genes & …, 2007 - genesdev.cshlp.org
MicroRNAs (miRNAs) are incorporated into miRNP complexes and regulate protein
expression post-transcriptionally through binding to 3′-untranslated regions of target …

Sleep deprivation and the epigenome

ME Gaine, S Chatterjee, T Abel - Frontiers in neural circuits, 2018 - frontiersin.org
Sleep deprivation disrupts the lives of millions of people every day and has a profound
impact on the molecular biology of the brain. These effects begin as changes within a …