Background—A variety of studies carried out using either human subjects or laboratory
animals suggest that vitamin D and its analogues possess important beneficial activity in the …

Blimp1, a zinc-finger containing DNA-binding transcriptional repressor, functions as a
master regulator of B cell terminal differentiation. Considerable evidence suggests that …

The T-box transcription factor eomesodermin (Eomes) has been implicated as an important
component in germ layer induction and patterning in vertebrate embryos. In the mouse …

Autotaxin (ATX) is a secreted glycoprotein widely present in biological fluids, originally
isolated from the supernatant of melanoma cells as an autocrine motility stimulation factor …

Three mouse lines expressing Cre recombinase under the control of the human K14
promoter induced specific deletion of loxP flanked target sequences in the epidermis, in …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor involved in
diverse biological processes including adipocyte differentiation, glucose homeostasis, and …

The role of Notch signaling in general and presenilin in particular was analyzed during
mouse somitogenesis. We visualize cyclical production of activated Notch (NICD) and …

The c-Myc protein has been implicated in playing a pivotal role in regulating the expression
of a large number of genes involved in many aspects of cellular function. Consistent with this …

Disruptions of the human FOXP2 gene cause problems with articulation of complex speech
sounds, accompanied by impairment in many aspects of language ability. The FOXP2/Foxp2 …

Anterior mesoderm (AM) and definitive endoderm (DE) progenitors represent the earliest
embryonic cell types that are specified during germ layer formation at the primitive streak …