The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

Aims: The N6-methyladenosine (m 6 A) modification plays an important role in various
biological processes, but its role in atherosclerosis remains unknown. The aim of this study …

PA28 (also known as 11S, REG or PSME) is a family of proteasome regulators whose
members are widely present in many of the eukaryotic supergroups. In jawed vertebrates …

The neuro-immune regulation is associated with homeostasis of the intestine. Intestinal
group 3 innate lymphoid cells (ILC3s) are tissue-resident lymphocytes whose functions are …

Rationale: The immature presentation of human induced pluripotent stem cell–derived
cardiomyocytes (iPSC-CMs) is currently a challenge for their application in disease …

Accumulating evidence has elucidated that hyperlipidemia is closely associated with an
increasing prevalence of CVDs (cardiovascular diseases) because of endothelial …

Purpose: Colorectal cancer is one of the most commonly diagnosed cancers closely
associated with inflammation and hyperactive growth. We previously demonstrated a …

REGγ, a proteasome activator belonging to the 11S (otherwise known as REG, PA28, or
PSME) proteasome activator family, is widely present in many eukaryotes. By binding to the …

Increasing incidence of inflammatory bowel disorders demands a better understanding of
the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that …

Anaplastic thyroid cancer (ATC) is the most aggressive human thyroid malignancy,
characterized by dedifferentiation and resistance to radioiodine therapy. The underlying …