The role of bile acids in carcinogenesis

T Režen, D Rozman, T Kovács, P Kovács… - Cellular and molecular …, 2022 - Springer
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Orchestration of MUC2—The key regulatory target of gut barrier and homeostasis: A review

Y Liu, Z Yu, L Zhu, S Ma, Y Luo, H Liang, Q Liu… - International Journal of …, 2023 - Elsevier
The gut mucosa of human is covered by mucus, functioning as a crucial defense line for the
intestine against external stimuli and pathogens. Mucin2 (MUC2) is a subtype of secretory …

Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role

J Yu, Z Xu, J Guo, K Yang, J Zheng, X Sun - Cell death discovery, 2021 - nature.com
The complex interaction between tumor-associated macrophages (TAMs) and tumor cells
through several soluble factors and signaling is essential for colorectal cancer (CRC) …

Natural compounds targeting nuclear receptors for effective cancer therapy

M Hegde, S Girisa, N Naliyadhara, A Kumar… - Cancer and Metastasis …, 2023 - Springer
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate
gene expression both spatially and temporally. Numerous biochemical, physiological, and …

Bile reflux and hypopharyngeal cancer

DP Vageli, SG Doukas, PG Doukas… - Oncology …, 2021 - spandidos-publications.com
Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …

Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review

Q He, L Liu, J Wei, J Jiang, Z Rong, X Chen… - Cell Death …, 2022 - nature.com
Gastric intestinal metaplasia (IM) is a precancerous lesion that increases the risk of
subsequent gastric cancer (GC) development. Therefore, the mechanism of IM has been the …

Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

JS Fleishman, S Kumar - Signal Transduction and Targeted Therapy, 2024 - nature.com
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …

[HTML][HTML] Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products

F Xia, LP Wen, BC Ge, YX Li, FP Li… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is among the most remarkable public health concerns
globally. Accumulating research evidence documents that alteration of gut microbiota has an …

[HTML][HTML] Tanshinone IIA protects intestinal epithelial cells from deoxynivalenol-induced pyroptosis

C Zhang, F Chen, Y Wang, K Zhang, X Yang… - … and Environmental Safety, 2024 - Elsevier
Deoxynivalenol (DON) is the most common mycotoxin in food and feed, which can cause
undesirable effects, including diarrhea, emesis, weight loss, and growth delay in livestock …

Diagnostic principles for chronic gastritis associated with duodenogastric reflux

MA Livzan, SI Mozgovoi, OV Gaus, DS Bordin… - Diagnostics, 2023 - mdpi.com
This article systematizes available data from the literature on biliary gastritis (BG) in order to
increase the awareness of specialists about the latest possibilities for diagnosing the …