The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a …

Delirium, a form of acute brain dysfunction, is very common in the critically ill adult patient
population. Although its pathophysiology is poorly understood, multiple factors associated …

Objectives: The severe acute respiratory syndrome coronavirus 2 pandemic has stretched
ICU resources in an unprecedented fashion and outstripped personal protective equipment …

Critical Care Medicine www. ccmjournal. org 1465 of GRADE methodology ensures a
systematic and transparent approach (8), the basis for determining the strength and quality …

Intravenous fluids (IVFs) are the most common drugs administered in the intensive care unit.
Despite the ubiquitous use, IVFs are not benign and carry significant risks associated with …

The recent article by Kotfis and colleagues provides great insight regarding newly identified
COVID-related risk factors contributing to ICU delirium, while also presenting valid potential …

The opioid epidemic has resulted in increased opioid‐related critical care admissions,
presenting challenges in acute pain management. Limited guidance exists in the …

Because the liver plays a major role in metabolic homeostasis and secretion of clotting
factors and inflammatory innate immune proteins, there is interest in understanding the …

OBJECTIVES: Describe the efficacy and safety of guanfacine for dexmedetomidine weaning
in critically ill patients. DESIGN: Retrospective descriptive analysis. SETTING: Six hundred …

Critically ill patients commonly experience pain, and the provision of analgesia is an
essential component of intensive care unit (ICU) care. Opioids are the mainstay of pain …