Simple Summary Novel therapeutic targets are needed to improve treatments of aggressive
cancers and viral diseases. Tetraspanins represent an emerging class of anticancer targets …

In the present minireview, we intend to provide a brief history of the field of CD9 involvement
in oncogenesis and in the metastatic process of cancer, considering its potential value as a …

The transcription factors signal transducer and activator of transcription 5A (STAT5A) and
STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have …

The interaction between leukemia cells and the bone microenvironment is known to provide
drug resistance in leukemia cells. This phenomenon, called cell adhesion-mediated drug …

Abstract Background Cancer‐associated fibroblasts (CAFs), integral to the tumour
microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or …

The outcomes of children with acute lymphoblastic leukemia (ALL) have been incrementally
improved with risk-directed chemotherapy but therapy responses remain heterogeneous …

Background Gastric cancer (GC) is one of the most common tumours in East Asia countries
and is associated with Helicobacter pylori infection. H. pylori utilizes virulence factors, CagA …

Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia
(AML), direct implementation in children is challenging due to inherent differences in …

Mesenchymal stem cells (MSC) favour a scenario where leukemic cells survive. The protein
kinase C (PKC) is essential to confer MSC support to leukemic cells and may be responsible …

Acute lymphoblastic leukemias (ALL) are the most frequent cancer in children and derive
most often from B-cell precursors. Current survival rates roughly reach 90% at 10 years from …