Aromatase inhibition is considered a legitimate approach for the treatment of ER-positive
(ER+) breast cancer as it accounts for more than 70% of breast cancer cases. Aromatase …

Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are
hormones that contribute to the growth of certain types of breast cancer. In particular …

Cancer is a multifaceted disease. With the development of multi drug resistance, the need
for the arousal of novel targets in order to avoid these drawbacks increased. A new series of …

In this study, we developed a series of new aromatase MAO-B dual inhibitors against breast
cancer. Aromatase inhibitors are the most commonly used drugs clinically for breast cancer …

The discovery of novel anti-cancer drugs motivated us to synthesize a new series of triple 1,
2, 3-triazole-based arm scaffolds featuring distinct un/functionalized alkyl and/or aryl side …

Background/Objectives: The synthesis of (E)-1-(1, 3-diphenylallyl)-1 H-1, 2, 4-triazoles and
related compounds as anti-mitotic agents with activity in breast cancer was investigated …

This Special Issue of Pharmaceuticals is devoted to significant advances achieved in the
field of Anticancer Drugs in 2021. Recent findings and trends in the design, synthesis and …

This study aimed to synthesize novel compounds as more effective carbonic anhydrase II
inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy) phenyl)-4, 5-diphenyl-1H …

Cancer is a multifaceted disease. With the development of multi drug resistance, the need
for the arousal of novel targets in order to avoid these drawbacks increased. A new series of …

In this study, imidazole derivative compounds were synthesized using the Debus-
Radziszewski method. The chemical structures of the compounds were characterized by …