[HTML][HTML] Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

[HTML][HTML] Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

High-dose methylprednisolone for acute traumatic spinal cord injury: a meta-analysis

Z Liu, Y Yang, L He, M Pang, C Luo, B Liu, L Rong - Neurology, 2019 - AAN Enterprises
Objective Due to the continuing debates on the utility of high-dose methylprednisolone (MP)
early after acute spinal cord injury (ASCI), we aimed to evaluate the therapeutic and adverse …

A clinical practice guideline for the management of patients with acute spinal cord injury: recommendations on the use of methylprednisolone sodium succinate

MG Fehlings, JR Wilson, LA Tetreault… - Global spine …, 2017 - journals.sagepub.com
Introduction: The objective of this guideline is to outline the appropriate use of
methylprednisolone sodium succinate (MPSS) in patients with acute spinal cord injury (SCI) …

Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives

JCT Chio, KJ Xu, P Popovich, S David… - Experimental …, 2021 - Elsevier
Spinal cord injury (SCI) has a complex pathophysiology. Following the initial physical
trauma to the spinal cord, which may cause vascular disruption, hemorrhage, mechanical …

[HTML][HTML] Prolonged inflammation leads to ongoing damage after spinal cord injury

JM Kwiecien, W Dabrowski, B Dąbrowska-Bouta… - PloS one, 2020 - journals.plos.org
The pathogenesis of spinal cord injury (SCI) remains poorly understood and treatment
remains limited. Emerging evidence indicates that post-SCI inflammation is severe but the …

[HTML][HTML] Milestones and current achievements in development of multifunctional bioscaffolds for medical application

J Litowczenko, MJ Woźniak-Budych, K Staszak… - Bioactive materials, 2021 - Elsevier
Tissue engineering (TE) is a rapidly growing interdisciplinary field, which aims to restore or
improve lost tissue function. Despite that TE was introduced more than 20 years ago …

Methylprednisolone for the treatment of patients with acute spinal cord injuries: a systematic review and meta-analysis

N Evaniew, EP Belley-Côté, N Fallah… - Journal of …, 2016 - liebertpub.com
Previous meta-analyses of methylprednisolone (MPS) for patients with acute traumatic
spinal cord injuries (TSCIs) have not addressed confidence in the quality of evidence used …

[HTML][HTML] Clinical neurorestorative therapeutic guidelines for spinal cord injury (IANR/CANR version 2019)

H Huang, W Young, S Skaper, L Chen… - Journal of orthopaedic …, 2020 - Elsevier
Functional restoration after spinal cord injury (SCI) is one of the most challenging tasks in
neurological clinical practice. With a view to exploring effective neurorestorative methods in …

Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target

NE Scholpa, RG Schnellmann - Journal of Pharmacology and Experimental …, 2017 - ASPET
Spinal cord injury (SCI) is characterized by an initial trauma followed by a progressive
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …