Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

Abstract Cornelia de Lange syndrome (CdLS) is an archetypical genetic syndrome that is
characterized by intellectual disability, well-defined facial features, upper limb anomalies …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Complex genomes show intricate organization in three-dimensional (3D) nuclear space.
Current models posit that cohesin extrudes loops to form self-interacting domains delimited …

Higher-order chromatin structure regulates gene expression, and mutations in proteins
mediating genome folding underlie developmental disorders known as cohesinopathies …

Bromodomain and extraterminal (BET) proteins bind acetylated lysine residues in histones
and nonhistone proteins via tandem bromodomains and regulate chromatin dynamics …

Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore
compartment in CD4+ T cells. However, the genomic features of these genes and the …

Gene transcription by RNA polymerase II (Pol II) is under control of promoters and distal
regulatory elements known as enhancers. Enhancers are themselves transcribed by Pol II …