Anthelmintic resistance in Haemonchus contortus: history, mechanisms and diagnosis

AC Kotze, RK Prichard - Advances in parasitology, 2016 - Elsevier
Haemonchus contortus has shown a great ability to develop resistance to anthelmintic
drugs. In many instances, resistance has appeared less than 10 years after the introduction …

[HTML][HTML] Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor …

AC Kotze, PW Hunt, P Skuce… - International Journal for …, 2014 - Elsevier
Anthelmintic resistance has a great impact on livestock production systems worldwide, is an
emerging concern in companion animal medicine, and represents a threat to our ongoing …

Haemonchosis: A challenging parasitic infection of sheep and goats

KV Arsenopoulos, GC Fthenakis, EI Katsarou… - Animals, 2021 - mdpi.com
Simple Summary The paper reviews the challenges regarding haemonchosis, a common
parasitic infection of sheep and goats, caused by Haemonchus parasites. The disease …

Genomic landscape of drug response reveals mediators of anthelmintic resistance

SR Doyle, R Laing, D Bartley, A Morrison, N Holroyd… - Cell Reports, 2022 - cell.com
Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment.
Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is …

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

R Laing, T Kikuchi, A Martinelli, IJ Tsai, RN Beech… - Genome biology, 2013 - Springer
Background The small ruminant parasite Haemonchus contortus is the most widely used
parasitic nematode in drug discovery, vaccine development and anthelmintic resistance …

[HTML][HTML] Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles

CM Dilks, SR Hahnel, Q Sheng, L Long… - International Journal for …, 2020 - Elsevier
Infections by parasitic nematodes inflict a huge burden on the health of humans and
livestock throughout the world. Anthelmintic drugs are the first line of defense against these …

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles

SR Hahnel, S Zdraljevic, BC Rodriguez, Y Zhao… - PLoS …, 2018 - journals.plos.org
Benzimidazoles (BZ) are essential components of the limited chemotherapeutic arsenal
available to control the global burden of parasitic nematodes. The emerging threat of BZ …

Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance

JS Gilleard - Parasitology, 2013 - cambridge.org
Anthelmintic resistance is a major problem for the control livestock parasites and a potential
threat to the sustainability of community-wide treatment programmes being used to control …

Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum

S Kitchen, R Ratnappan, S Han, C Leasure… - International journal for …, 2019 - Elsevier
Soil-transmitted nematodes infect over a billion people and place several billion more at risk
of infection. Hookworm disease is the most significant of these soil-transmitted nematodes …

Complementary approaches with free-living and parasitic nematodes to understanding anthelmintic resistance

J Wit, CM Dilks, EC Andersen - Trends in parasitology, 2021 - cell.com
Anthelmintic drugs are the major line of defense against parasitic nematode infections, but
the arsenal is limited and resistance threatens sustained efficacy of the available drugs …