Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the
third leading cause of death worldwide. COPD is characterized by chronic airway …

Cytokines are key players in the initiation and propagation of inflammation in chronic
inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD) …

In patients with chronic kidney disease (CKD), adverse outcomes such as systemic
inflammation and anemia are contributing pathologies which increase the risks for …

Circulating levels of fibroblast growth factor (FGF) 23 are associated with systemic
inflammation and increased mortality in chronic kidney disease. α-Klotho, a co-receptor for …

Fibroblast growth factor 23 (FGF 23) is mainly produced in the bone and, upon secretion,
forms a complex with a FGF receptor and coreceptor αKlotho. FGF 23 can exert several …

Fibroblast growth factor 23 (FGF23) plays a key role in the complex network between the
bones and other organs. Initially, it was thought that FGF23 exclusively regulated phosphate …

Chronic illnesses rarely present in a vacuum, devoid of other complications, and chronic
kidney disease is hardly an exception. Comorbidities associated with chronic kidney …

Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease
(CVD). Diverse studies have shown a bidirectional relationship between Klotho and …

Klotho-and beclin 1-driven autophagy extends life. We examined the role of beclin 1 in
modifying acute kidney injury (AKI) and whether beclin 1 mediates Klotho's known …