Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration
F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …
Novel therapeutic approaches for Alzheimer's disease: an updated review
Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
Metabolic dysregulation contributes to the progression of Alzheimer's disease
X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease
APOE and Trem2 are major genetic risk factors for Alzheimer's disease (AD), but how they
affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific …
affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific …
Linking the amyloid, tau, and mitochondrial hypotheses of Alzheimer's disease and identifying promising drug targets
Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …
Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges
Microglia are specialized dynamic immune cells in the central nervous system (CNS) that
plays a crucial role in brain homeostasis and in disease states. Persistent …
plays a crucial role in brain homeostasis and in disease states. Persistent …
Cholinergic modulation of glial function during aging and chronic neuroinflammation
R Gamage, I Wagnon, I Rossetti, R Childs… - Frontiers in Cellular …, 2020 - frontiersin.org
Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …
[HTML][HTML] TREM2 ectodomain and its soluble form in Alzheimer's disease
J Yang, Z Fu, X Zhang, M Xiong, L Meng… - Journal of …, 2020 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed
on the surface of microglia. It mediates multiple pathophysiological processes in various …
on the surface of microglia. It mediates multiple pathophysiological processes in various …
Insulin resistance in peripheral tissues and the brain: a tale of two sites
The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …