Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
Key players in the immune response to biomaterial scaffolds for regenerative medicine
L Chung, DR Maestas Jr, F Housseau… - Advanced drug delivery …, 2017 - Elsevier
The compatibility of biomaterials is critical to their structural and biological function in
medical applications. The immune system is the first responder to tissue trauma and to a …
medical applications. The immune system is the first responder to tissue trauma and to a …
IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression
Abstract Aims SARS-CoV-2, an infectious agent behind the ongoing COVID-19 pandemic,
induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in …
induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in …
CRISPR screening of CAR T cells and cancer stem cells reveals critical dependencies for cell-based therapies
Glioblastoma (GBM) contains self-renewing GBM stem cells (GSC) potentially amenable to
immunologic targeting, but chimeric antigen receptor (CAR) T-cell therapy has demonstrated …
immunologic targeting, but chimeric antigen receptor (CAR) T-cell therapy has demonstrated …
Biologics for chronic rhinosinusitis with nasal polyps
C Bachert, N Zhang, C Cavaliere, W Weiping… - Journal of Allergy and …, 2020 - Elsevier
With the increasing recognition of the role of type 2 immune responses in chronic
rhinosinusitis, its severity, recurrence, and comorbidities, several biologics targeting IL-4, IL …
rhinosinusitis, its severity, recurrence, and comorbidities, several biologics targeting IL-4, IL …
AT cell resilience model associated with response to immunotherapy in multiple tumor types
Despite breakthroughs in cancer immunotherapy, most tumor-reactive T cells cannot persist
in solid tumors due to an immunosuppressive environment. We developed Tres (tumor …
in solid tumors due to an immunosuppressive environment. We developed Tres (tumor …
Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
Cellular immunity is critical for controlling intracellular pathogens, but individual cellular
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …
Amyloid-β specific regulatory T cells attenuate Alzheimer's disease pathobiology in APP/PS1 mice
Abstract Background Regulatory T cells (Tregs) maintain immune tolerance. While Treg-
mediated neuroprotective activities are now well-accepted, the lack of defined antigen …
mediated neuroprotective activities are now well-accepted, the lack of defined antigen …
IL-4 drives exhaustion of CD8+ CART cells
Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part
due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion …
due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion …
Coengineering specificity, safety, and function into T cells for cancer immunotherapy
GMP Giordano Attianese, S Ash… - Immunological …, 2023 - Wiley Online Library
Adoptive T‐cell transfer (ACT) therapies, including of tumor infiltrating lymphocytes (TILs)
and T cells gene‐modified to express either a T cell receptor (TCR) or a chimeric antigen …
and T cells gene‐modified to express either a T cell receptor (TCR) or a chimeric antigen …