It is now plausible to dock libraries of 10 million molecules against targets over several days
or weeks. When the molecules screened are commercially available, they may be rapidly …

Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

Absent in animals and with only seven enzymatic reactions toward the synthesis of
chorismate and aromatic amino acids, the shikimate pathway is a crucial target for …

Roughly a third of the world's population is estimated to have latent Mycobacterium
tuberculosis infection, being at risk of developing active tuberculosis (TB) during their …

Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …

Mycobacterium tuberculosis (Mtb) is an endemic bacterium worldwide that causes
tuberculosis (TB) and involves long-term treatment that is not always effective. In this context …

Emergence of antibiotic‐resistant Mycobacterium tuberculosis (M. tuberculosis) restricts the
availability of drugs for the treatment of tuberculosis, which leads to the increased morbidity …

In this study, we have investigated the enzyme shikimate 5-dehydrogenase from the
causative agent of tuberculosis, Mycobacterium tuberculosis. We have employed a mixture …

The mycobacterial mel2 locus (mycobacterial enhanced infection locus, Rv1936-1941) is
Mycobacterium marinum and M. tuberculosis specific, which can withstand reactive oxygen …

Introduction: Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains the
deadliest infectious disease in the world with one-third of the world's population thought to …