[HTML][HTML] Cognitive, emotional and psychological manifestations in amyotrophic lateral sclerosis at baseline and overtime: a review

S Benbrika, B Desgranges, F Eustache… - Frontiers in …, 2019 - frontiersin.org
It is now well recognized that, in addition to motor impairment, amyotrophic lateral sclerosis
(ALS) may cause extra-motor clinical signs and symptoms. These can include the alteration …

[HTML][HTML] Clinical and radiological markers of extra-motor deficits in amyotrophic lateral sclerosis

F Christidi, E Karavasilis, M Rentzos, N Kelekis… - Frontiers in …, 2018 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem
disorder with considerable extra-motor involvement. The neuropsychological manifestations …

MRI clustering reveals three ALS subtypes with unique neurodegeneration patterns

HHG Tan, HJ Westeneng, AD Nitert… - Annals of …, 2022 - Wiley Online Library
Objective The purpose of this study was to identify subtypes of amyotrophic lateral sclerosis
(ALS) by comparing patterns of neurodegeneration using brain magnetic resonance …

Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations

P Bede, RH Chipika, F Christidi… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objective Cerebellar disease burden and cerebro-cerebellar connectivity alterations are
poorly characterised in amyotrophic lateral sclerosis (ALS) despite the likely contribution of …

[HTML][HTML] The spectrum of cognitive dysfunction in amyotrophic lateral sclerosis: an update

KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive dysfunction is an important non-motor symptom in amyotrophic lateral sclerosis
(ALS) that has a negative impact on survival and caregiver burden. It shows a wide spectrum …

[HTML][HTML] Hippocampal metabolic alterations in amyotrophic lateral sclerosis: a magnetic resonance spectroscopy study

F Christidi, GD Argyropoulos, E Karavasilis… - Life, 2023 - mdpi.com
Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis
(ALS) has been overwhelmingly applied to motor regions to date and our understanding of …

[HTML][HTML] Frontotemporal pathology in motor neuron disease phenotypes: Insights from neuroimaging

MC McKenna, P Corcia, P Couratier, WF Siah… - Frontiers in …, 2021 - frontiersin.org
Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

[HTML][HTML] Neurometabolic alterations in motor neuron disease: insights from magnetic resonance spectroscopy

F Christidi, E Karavasilis, GD Argyropoulos… - Journal of integrative …, 2022 - imrpress.com
Magnetic resonance spectroscopy (MRS) has contributed important academic insights in
motor neuron diseases (MNDs), particularly in amyotrophic lateral sclerosis (ALS). Over the …

The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools

P Bede, G Querin, PF Pradat - Current opinion in neurology, 2018 - journals.lww.com
The changing landscape of motor neuron disease imaging: the... : Current Opinion in
Neurology The changing landscape of motor neuron disease imaging: the transition from …

[HTML][HTML] Basal ganglia alterations in amyotrophic lateral sclerosis

V Castelnovo, E Canu, F De Mattei, M Filippi… - Frontiers in …, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) has traditionally been associated with brain damage
involving the primary motor cortices and corticospinal tracts. In the recent decades, most of …