Benign prostatic hyperplasia (BPH) is the noncancerous proliferation of the prostate gland
associated with benign prostatic obstruction and lower urinary tract symptoms (LUTS) such …

The skin, especially the pilosebaceous unit composed of sebaceous glands and hair
follicles, can synthesize androgens de novo from cholesterol or by locally converting …

Skin diseases are a class of common and frequently occurring diseases that significantly
impact daily lives. Currently, the limited effective therapeutic drugs are far from meeting the …

A series of umbelliferone derivatives was prepared and their 5α-reductase type 1 inhibitory
activities were evaluated in cell culture systems. Our studies have identified a new series of …

The enzyme 5α-reductase (5αR) catalyses the reduction of testosterone (T) into the more
potent androgen dihydrotestosterone (DHT). The abnormal production of DHT is associated …

Objective Calcitriol analogues might represent an interesting new therapy for benign
prostate hyperplasia (BPH). We here report the preclinical characterization of BXL-628, an …

Alopecia has emerged as a global concern, extending beyond the middle-aged and elderly
population and increasingly affecting younger individuals. Despite its growing prevalence …

We have recently found that analog V (BXL-353, a calcitriol analog) inhibits growth factor
(GF)-stimulated human benign prostate hyperplasia (BPH) cell proliferation by disrupting …

Baylis–Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford
adducts that undergo reductive cyclisation to quinoline derivatives. The chemo-and …

An effective synthesis of the multi ring-fused benzoindoloquinolizines has been
accomplished by Cu (I)-mediated and MW-assisted C–Namide bond formation of benzo [a] …