Simple Summary Cancer-associated fibroblasts (CAFs) are found in the tumor
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in
the tumor microenvironment, leading to immunosuppressive features. Here, we employed …

Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung
cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in …

Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the
major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major …

Despite advances in anticancer therapy, the prognosis of gastric cancer (GC) remains
unsatisfactory. Research in recent years has shown that the malignant behavior of cancer is …

The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …

The tumor microenvironment (TME) is a hypoxic, acidic, and immune/inflammatory cell–
enriched milieu that plays crucial roles in tumor development, growth, progression, and …

Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune
checkpoint blockade has improved survival for many patients with NSCLC, but most fail to …

The interplay between apoptotic cancer cells and the tumor microenvironment modulates
cancer progression and metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role …