Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Summary MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-
strand break repair (DSBR), detection, and signaling; yet, how its endo-and exonuclease …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

The opposing activities of 53BP1 and BRCA1 influence pathway choice in DNA double-
strand-break repair. How BRCA1 counteracts the inhibitory effect of 53BP1 on DNA …

Radiotherapy (RT) has been applied for decades as a treatment modality in the
management of various types of cancer. Ionizing radiation induces tumor cell death, which in …

DNA non-homologous end-joining (NHEJ) and homologous recombination (HR) represent
the major DNA double strand break (DSB) pathways in mammalian cells, whilst ataxia …

Maintenance of genome integrity and stability is a critical responsibility of the DNA damage
response (DDR) within cells, such that any disruption in this kinase-based signaling …

A DNA double-strand break (DSB) has long been recognized as a severe cellular lesion,
potentially representing an initiating event for carcinogenesis or cell death. The evolution of …

The DNA damage response pathways involve processes of double-strand break (DSB)
repair and cell cycle checkpoint control to prevent or limit entry into S phase or mitosis in the …