Phage display derived monoclonal antibodies: from bench to bedside

MA Alfaleh, HO Alsaab, AB Mahmoud… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Treating the different phenotypes of Behçet's syndrome

A Bettiol, G Hatemi, L Vannozzi, A Barilaro… - Frontiers in …, 2019 - frontiersin.org
Behçet's syndrome (BS) is a multisystemic vasculitis, characterized by different clinical
involvements, including mucocutaneous, ocular, vascular, neurological, and gastrointestinal …

Anti–tumor necrosis factor α versus tocilizumab in the treatment of refractory uveitic macular edema: a multicenter study from the French Uveitis Network

M Leclercq, A Andrillon, G Maalouf, P Sève, P Bielefeld… - Ophthalmology, 2022 - Elsevier
Purpose To analyze the factors associated with response (control of ocular inflammation and
corticosteroid-sparing effect) to biologics (anti–tumor necrosis factor [TNF]-α agents and …

Biotherapies in uveitis

M Leclercq, AC Desbois, F Domont, G Maalouf… - Journal of clinical …, 2020 - mdpi.com
Non-infectious uveitis (NIU) represents one of the leading causes of blindness in developed
countries. The therapeutic strategy aims to rapidly control intra-ocular inflammation, prevent …

Biologic and advanced immunomodulating therapeutic options for sarcoidosis: a clinical update

ON Obi, EE Lower, RP Baughman - Expert Review of Clinical …, 2021 - Taylor & Francis
Introduction: Sarcoidosis is a multi-organ disease with a wide range of clinical
manifestations and outcomes. A quarter of sarcoidosis patients require long-term treatment …

Drug retention rate and causes of discontinuation of adalimumab in uveitis: real-world data from the Biotherapies in uveitis (BioÚvea) Study Group

V Llorenç, M Cordero-Coma, A Blanco-Esteban… - Ophthalmology, 2020 - Elsevier
Purpose To study the drug retention rate (DRR), causes, and predictors of discontinuation of
adalimumab (ADA) in a real-world uveitis setting. Design Multicentric, nationwide, registry …

Adalimumab effectively controls both anterior and posterior noninfectious uveitis associated with systemic inflammatory diseases: focus on Behçet's syndrome

E Silvestri, A Bitossi, A Bettiol, G Emmi, ML Urban… - …, 2020 - Springer
Background To compare the efficacy of Adalimumab (ADA) in noninfectious anterior uveitis
(AU) and posterior segment (PS) involvement, associated with different conditions, with a …

The role of biosimilars in uveitis: long-term real-world outcomes of the switch from original to biosimilar TNF-alpha inhibitors

C Fabiani, A Vitale, G Emmi, A Sgheri… - Frontiers in …, 2019 - frontiersin.org
Background: Recent expiry of patents for tumor necrosis factor (TNF)-α inhibitors has led to
the employment of biosimilars in clinical practice. The aim of the study was to identify any …

Comparative study of adalimumab versus conventional therapy in sight-threatening refractory Behcet's uveitis with vasculitis

S Yang, Z Huang, X Liu, H Li, L Xie, X Chen… - International …, 2021 - Elsevier
Background Anti-tumor necrosis factor-alpha was regarded as an option in treatment of non-
infectious uveitis. However, few studies in the far easter region have concentrated on this …

Long-Term safety and effectiveness of adalimumab in Japanese patients with noninfectious intermediate, posterior, or panuveitis: Post-marketing surveillance of 251 …

K Namba, T Kaburaki, H Tsuruga, Y Ogawa… - Ophthalmology and …, 2022 - Springer
Introduction The aim of this nationwide, prospective post-marketing surveillance was to
assess the safety and effectiveness of up to 52 weeks of adalimumab treatment in patients …