The emerging links between our gut microbiome and the central nervous system are
regarded as a paradigm shift in neuroscience with possible implications for not only …

Traditionally, irritable bowel syndrome has been considered to be a disorder with no known
underlying structural or biochemical explanation, but this concept is likely to be outdated. In …

Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints
arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity …

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is
characterized by abdominal pain and an altered defecation pattern. It affects between 5 and …

The gastrointestinal tract harbours the largest population of mast cells in the body; this highly
specialised leukocyte cell type is able to adapt its phenotype and function to the …

Chronic unexplained gastrointestinal symptoms impact more than 1 in 5 Americans and their
families; these disorders include the irritable bowel syndrome (IBS) and functional …

BACKGROUND: Subtle histopathologic features such as eosinophilia and increased mast
cells have been observed in functional gastrointestinal disorders (FGIDs), including …

Abstract Background & Aims Increases in mucosal immune cells have frequently been
observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely …

Background Irritable bowel syndrome (IBS) and other functional bowel disorders (FBDs) are
prevalent disorders with altered microbiota. Prebiotics positively augment gut microbiota and …

The aetiology and pathology of IBS, a functional bowel disorder thought to lack an organic
cause, is largely unknown. However, studies suggest that various features, such as altered …