The RTS, S vaccine has recently been recommended for implementation as a childhood
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …

Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …

Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and
limited treatment options. Here we provide a comprehensive census of the bone marrow …

The need to discover, design and develop novel anti-malaria agent that are capable of
treating and providing prophylaxis cover for malaria infections has become paramount …

Autoimmune diseases disproportionately affect females more than males. The XX sex
chromosome complement is strongly associated with susceptibility to autoimmunity. Xist …

Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of
the critical pending tasks required to establish a framework for the systematic understanding …

Chronic infectious diseases have a substantial impact on the human B cell compartment
including a notable expansion of B cells here termed atypical B cells (ABCs). Using …

Background Data on immune responses to SARS-CoV-2 in patients with Primary Antibody
Deficiencies (PAD) are limited to infected patients and to heterogeneous cohorts after …

Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is
known about the B cell memory of persistent IgE responses. Here, we describe, in human …