Symposium review: Genetics, genome-wide association study, and genetic improvement of dairy fertility traits

L Ma, JB Cole, Y Da, PM VanRaden - Journal of dairy science, 2019 - Elsevier
Before fertility traits were incorporated into selection, dairy cattle breeding primarily focused
on production traits, which resulted in an unfavorable decline in the reproductive …

In it for the long run: perspectives on exploiting long-read sequencing in livestock for population scale studies of structural variants

TV Nguyen, CJ Vander Jagt, J Wang… - Genetics Selection …, 2023 - Springer
Studies have demonstrated that structural variants (SV) play a substantial role in the
evolution of species and have an impact on Mendelian traits in the genome. However, unlike …

A comprehensive biomedical variant catalogue based on whole genome sequences of 582 dogs and eight wolves

V Jagannathan, C Drögemüller, T Leeb… - Animal …, 2019 - Wiley Online Library
The domestic dog serves as an excellent model to investigate the genetic basis of disease.
More than 400 heritable traits analogous to human diseases have been described in dogs …

[HTML][HTML] Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility

JB Cole, DJ Null, PM VanRaden - Journal of dairy science, 2016 - Elsevier
Phenotypes from the August 2015 US national genetic evaluation were used to compute
phenotypic effects of 18 recessive haplotypes in Ayrshire (n= 1), Brown Swiss (n= 5) …

Гаплотипы фертильности голштинского скота

НА Зиновьева - Сельскохозяйственная биология, 2016 - cyberleninka.ru
Голштинскую породу крупного рогатого скота разводят по крайней мере в 161 стране,
на долю животных голштинской и голштинизированной черно-пестрой пород в общем …

Loss of function mutations in essential genes cause embryonic lethality in pigs

MFL Derks, AB Gjuvsland, M Bosse, MS Lopes… - PLoS …, 2019 - journals.plos.org
Lethal recessive alleles cause pre-or postnatal death in homozygous affected individuals,
reducing fertility. Especially in small size domestic and wild populations, those alleles might …

High-resolution structural variants catalogue in a large-scale whole genome sequenced bovine family cohort data

YL Lee, M Bosse, H Takeda, GCM Moreira, L Karim… - BMC genomics, 2023 - Springer
Abstract Background Structural variants (SVs) are chromosomal segments that differ
between genomes, such as deletions, duplications, insertions, inversions and …

Ruminant-specific retrotransposons shape regulatory evolution of bovine immunity

CJ Kelly, CG Chitko-McKown, EB Chuong - Genome Research, 2022 - genome.cshlp.org
Cattle are an important livestock species, and mapping the genomic architecture of
agriculturally relevant traits such as disease susceptibility is a major challenge in the bovine …

Removal of alleles by genome editing (RAGE) against deleterious load

M Johnsson, RC Gaynor, J Jenko, G Gorjanc… - Genetics Selection …, 2019 - Springer
Background In this paper, we simulate deleterious load in an animal breeding program, and
compare the efficiency of genome editing and selection for decreasing it. Deleterious …

Four novel candidate causal variants for deficient homozygous haplotypes in Holstein cattle

IM Häfliger, M Spengeler, FR Seefried… - Scientific reports, 2022 - nature.com
Mendelian variants can determine both insemination success and neonatal survival and
thus influence fertility and rearing success of cattle. We present 24 deficient homozygous …