A number of proteins anchored on the cell surface function to protect host tissues from
bystander injury when complement is activated. In humans, they include decay-accelerating …

Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor
(uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide …

Tertiary lymphoid tissues (TLTs) have been observed in the meninges of multiple sclerosis
(MS) patients, but the stromal cells and molecular signals that support TLTs remain unclear …

Decay-accelerating factor ([DAF] CD55) is a glycosylphosphatidylinositol-anchored
membrane inhibitor of complement with broad clinical relevance. Here, we establish an …

Microglia and macrophages, one a brain-resident, the other a mostly hematogenous cell
type, represent two related cell types involved in the brain pathology in multiple sclerosis …

This presentation highlights aspects of the immunobiology of the Guillain‐Barré syndromes
(GBS), the world's leading cause of acute autoimmune neuromuscular paralysis …

Traumatic brain injury (TBI) is the leading cause of disability and death in young adults. The
secondary neuroinflammation and neuronal damage that follows the primary mechanical …

Microglial priming predisposes the brain to neurodegeneration and affects disease
progression. The signal to switch from the quiescent to the primed state is unknown. We …

The complement system has been involved in the pathogenesis of multiple
neuroinflammatory and neurodegenerative conditions. In this review, we evaluated the …

Axonal loss is the principal cause of chronic disability in multiple sclerosis and experimental
autoimmune encephalomyelitis (EAE). In C57BL/6 mice with EAE induced by immunization …