The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Molecular epidemiologic studies of tuberculosis (TB) have focused largely on utilizing
molecular techniques to address short-and long-term epidemiologic questions, such as in …

Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and
cause disease, long-term epidemiological data indicate that humans represent a spill-over …

Before childhood vaccination was introduced in the 1950s, pertussis or whooping cough
was a major cause of infant death worldwide. Widespread vaccination of children was …

The Mycobacterium tuberculosis phoP mutant strain SO2 has previously been shown to
have reduced multiplication in mouse macrophages and in vivo using the mouse …

Tuberculosis (TB), an ancient human scourge, is a growing health problem in the
developing world. Approximately two million deaths each year are caused by TB, which is …

Two-component regulatory signal transduction systems are important elements of the
adaptative response of prokaryotes to a variety of environmental stimuli. Disruption of PhoP …

Coughing is a dynamic physiological process resulting from input of vagal sensory neurons
innervating the airways and perceived airway irritation. Although cough serves to protect …

Mycobacterium bovis Bacille Calmette-Guérin (BCG) was developed as an attenuated live
vaccine for tuberculosis control nearly a century ago. Despite being the most widely used …