Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS …

Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders
that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular …

Covalent amino acid modification significantly expands protein functional capability in
regulating biological processes. Tyrosine residues can undergo phosphorylation, sulfation …

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
syndrome is one of the most common mitochondrial disorders. Although the pathogenesis of …

Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its
roles remain controversial. Peroxynitrite (ONOO−), as a representative of reactive nitrogen …

Beyond the disorders recognized as mitochondrial diseases, abnormalities in function
and/or ultrastructure of mitochondria have been reported in several unrelated pathologies …

Excessive autophagy/mitophagy plays important roles during cerebral ischemia-reperfusion
(I/R) injury. Peroxynitrite (ONOO−), a representative reactive nitrogen species, mediates …

Primary mitochondrial diseases (PMD) refer to a group of severe, often inherited genetic
conditions due to mutations in the mitochondrial genome or in the nuclear genes encoding …

The type III intermediate filament proteins vimentin and GFAP are modulated by oxidants
and electrophiles, mainly through perturbation of their single cysteine residues. Desmin, the …

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
syndrome is one of the most frequent maternally inherited mitochondrial disorders. The …