The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Mitochondrial oxidative damage contributes to a wide range of pathologies, including
cardiovascular disorders and neurodegenerative diseases. Therefore, protecting …

Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum
of neurodegenerative disorders, including Parkinson's disease (PD). We recently revealed …

Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial
health effects in vitro, in vivo and clinically. These therapeutic properties have long been …

• Introduction• Metabolism and transport of physiological polyamines• Are physiological
polyamines stress molecules?• Roles of physiological polyamines in oxidative stress …

Despite intensive research, no satisfactory therapeutic options have been found for aging
and age-related diseases. The British scientist Leslie Orgel stated that evolution is cleverer …

Sperm are susceptible to excessive reactive oxygen species (ROS). Spermine and
spermidine are secreted in large amounts by the prostate and potent natural free radical …

The polyamines spermidine and spermine are positively charged aliphatic molecules. They
are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein …

Inorganic polyphosphates are linear polymers of orthophosphate that modulate blood
clotting and inflammation. Polyphosphate accumulates in infectious microorganisms and is …