Decapentaplegic (Dpp), the fly homolog of the secreted mammalian BMP2/4 signaling
molecules, is involved in almost all aspects of fly development. Dpp has critical functions at …

The transforming growth factor β (TGF-β) family has a profound impact on the reproductive
function of various organisms. In this review, we discuss how highly conserved members of …

Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-
derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic …

Adult stem cells across diverse organs self-renew and differentiate to maintain tissue
homeostasis. How stem cells receive input to preserve tissue structure and function largely …

The extracellular matrix plays an essential role for stem cell differentiation and niche
homeostasis. Yet, the origin and mechanism of assembly of the stem cell niche …

The TRIM‐NHL family of proteins shares a conserved domain architecture and play crucial
roles in stem cell biology, fertility, and development. This review synthesizes new insights …

Stem cell self-renewal versus differentiation is regulated by the niche, which provides
localized molecules that favor self-renewal. In the Drosophila melanogaster female germline …

Eukaryotes possess a vast array of RNA-binding proteins (RBPs) that affect mRNAs in
diverse ways to control protein expression. Combinatorial regulation of mRNAs by RBPs is …

Pattern formation by bone morphogenetic proteins (BMPs) demonstrates remarkable
plasticity and utility in several contexts, such as early embryonic development, tissue …

Specialized microenvironments called niches regulate tissue homeostasis by controlling the
balance between stem cell self-renewal and the differentiation of stem cell daughters …