Lipogenesis inhibitors: therapeutic opportunities and challenges
B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
[HTML][HTML] Getting out what you put in: Copper in mitochondria and its impacts on human disease
Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
The SLC25 carrier family: important transport proteins in mitochondrial physiology and pathology
Members of the mitochondrial carrier family (SLC25) transport a variety of compounds
across the inner membrane of mitochondria. These transport steps provide building blocks …
across the inner membrane of mitochondria. These transport steps provide building blocks …
Molecular nature and physiological role of the mitochondrial calcium uniporter channel
BR Alevriadou, A Patel, M Noble… - … of Physiology-Cell …, 2021 - journals.physiology.org
Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …
Mitochondrial transport and metabolism of the vitamin B‐derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD+, and related diseases: A review
Multiple mitochondrial matrix enzymes playing key roles in metabolism require cofactors for
their action. Due to the high impermeability of the mitochondrial inner membrane, these …
their action. Due to the high impermeability of the mitochondrial inner membrane, these …
An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) …
YJ Chen, WF Hong, ML Liu, X Guo, YY Yu… - Cell Death & …, 2022 - nature.com
Abstract Solute carrier family 25 (SLC25) encodes transport proteins at the inner
mitochondrial membrane and functions as carriers for metabolites. Although SLC25 genetic …
mitochondrial membrane and functions as carriers for metabolites. Although SLC25 genetic …
The mitochondrial carnitine acyl-carnitine carrier (SLC25A20): molecular mechanisms of transport, role in redox sensing and interaction with drugs
The SLC25A20 transporter, also known as carnitine acyl-carnitine carrier (CAC), catalyzes
the transport of short, medium and long carbon chain acyl-carnitines across the …
the transport of short, medium and long carbon chain acyl-carnitines across the …
Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle
V Mavridou, MS King, S Tavoulari, JJ Ruprecht… - Nature …, 2022 - nature.com
Mitochondrial ADP/ATP carriers import ADP into the mitochondrial matrix and export ATP to
the cytosol to fuel cellular processes. Structures of the inhibited cytoplasmic-and matrix-open …
the cytosol to fuel cellular processes. Structures of the inhibited cytoplasmic-and matrix-open …
New and emerging research on solute carrier and ATP binding cassette transporters in drug discovery and development: outlook from the international transporter …
Enabled by a plethora of new technologies, research in membrane transporters has
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …
The mitochondrial citrate carrier SLC25A1/CIC and the fundamental role of citrate in cancer, inflammation and beyond
R Mosaoa, A Kasprzyk-Pawelec, HR Fernandez… - Biomolecules, 2021 - mdpi.com
The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in
a growing list of human diseases. CIC belongs to a large family of nuclear-encoded …
a growing list of human diseases. CIC belongs to a large family of nuclear-encoded …