In the past decade, numerous studies have demonstrated the close relationship between gut
microbiota and the occurrence and development of Alzheimer's disease (AD). However, the …

Ischemic stroke is the second cause of mortality and the first cause of long-term disability
constituting a serious socioeconomic burden worldwide. Approved treatments include …

Pharmacological modulation of glutamate has long been considered to be of immense
therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for …

Stroke is the largest contributor to global neurological disability-adjusted life-years, posing a
huge economic and social burden to the world. Though pharmacological recanalization with …

Here an overview is provided on therapeutic/neuroprotective effects of Lithium (Li+) in
neurodegenerative and psychiatric disorders focusing on the conspicuous action of Li+ …

The type 5 metabotropic glutamate receptor, mGlu5, has been proposed as a potential
therapeutic target for the treatment of several neurodegenerative diseases. In preclinical …

Huntington's disease (HD) is an inherited autosomal dominant neurodegenerative disorder
that leads to progressive motor and cognitive impairment. There are currently no available …

Huntington's disease (HD) is an inherited neurodegenerative disorder in which the striatum
is the most affected brain region. Although a chronic inflammatory microglial reaction that …

Huntington's disease (HD) arises from the abnormal expansion of CAG repeats in the
huntingtin gene (HTT), resulting in the production of the mutant huntingtin protein (mHTT) …

Glutamate, the major excitatory neurotransmitter in the brain exerts its effects via both
ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs). There are …