Simple Summary The microbiota can modulate immune responses and modify the
physiology of the human organism, thereby increasing infective risks and a neoplastic …

A biomarker is a characteristic that is objectively measured and evaluated as an indicator of
normal biologic processes, pathogenic processes, or pharmacologic responses to a …

BACKGROUND: P16INK4a is a biomarker for transforming HPV infections that could act as
an adjunct to current cytological and histological assessment of cervical smears and …

Human papillomavirus (HPV) infection of the genital tract is very common and normally
follows a benign clinical course; however, in an unfortunate minority of infected individuals, it …

Abstract The cyclin D‐Cdk4‐6/INK4/Rb/E2F pathway plays a key role in controlling cell
growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 …

In industrialized countries, population wide cytological screening programs using the Pap
test have led to a substantial reduction of the incidence of cervical cancer. Despite this …

The MCM proteins identify a group of ten conserved factors functioning in the replication of
the genomes of archae and eukaryotic organisms. Among these, MCM2–7 proteins are …

Strict regulation of DNA replication is of fundamental significance for the maintenance of
genome stability. Licensing of origins of DNA replication is a critical event for timely genome …

The accurate execution of DNA replication requires a strict control of the replication licensing
factors hCdt1 and hCdc6. The role of these key replication molecules in carcinogenesis has …

Purpose: To better understand the molecular mechanisms of malignant melanoma
progression and metastasis, gene expression profiling was done of primary melanomas and …