The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …
treatment of a wide range of diseases. The recent success of the two highly efficacious …
[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
Therapeutic messenger RNA vaccines enable delivery of whole antigens, which can be
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …
The molecular mechanism of RIG‐I activation and signaling
RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …
receptor that identifies molecular features common among dsRNA and ssRNA viral …
N6-methyladenosine modification controls circular RNA immunity
Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian
cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self …
cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
Human NLRP1 is a sensor for double-stranded RNA
S Bauernfried, MJ Scherr, A Pichlmair, KE Duderstadt… - Science, 2021 - science.org
INTRODUCTION The innate immune system constitutes the first line of host defense. To
detect pathogens, it uses a set of germline-encoded pattern recognition receptors (PRRs) …
detect pathogens, it uses a set of germline-encoded pattern recognition receptors (PRRs) …
Regulation of cGAS-and RLR-mediated immunity to nucleic acids
A Ablasser, S Hur - Nature immunology, 2020 - nature.com
Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the
structural similarity between those and host nucleic acids, mammalian cells have been able …
structural similarity between those and host nucleic acids, mammalian cells have been able …
Double-stranded RNA sensors and modulators in innate immunity
S Hur - Annual review of immunology, 2019 - annualreviews.org
Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …
defense in many organisms. We here discuss several families of dsRNA-binding proteins …