Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …
[HTML][HTML] SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populations
A Awadasseid, Y Wu, Y Tanaka… - International journal of …, 2021 - ncbi.nlm.nih.gov
The outbreak of the coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic apparently started in …
respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic apparently started in …
COVID-19: insights into virus–receptor interactions
The recent outbreak of Coronavirus Disease 2019 (COVID-19) calls for rapid mobilization of
scientists to probe and explore solutions to this deadly disease. A limited understanding of …
scientists to probe and explore solutions to this deadly disease. A limited understanding of …
Exploring nucleoside analogs: key targets in the viral life cycle-advancing strategies against SARS-CoV-2
R Garg, R Kumar, R Srivastava… - Medicinal Chemistry …, 2024 - Springer
The COVID-19 pandemic has been a major reason behind the increased research aimed at
the identification of effective antiviral agents. Among these, Nucleoside analogs have shown …
the identification of effective antiviral agents. Among these, Nucleoside analogs have shown …
Conformational flexibility and local frustration in the functional states of the SARS-CoV-2 spike B. 1.1. 7 and B. 1.351 variants: Mutation-induced allosteric modulation …
G Verkhivker - International Journal of Molecular Sciences, 2022 - mdpi.com
Structural and functional studies of the SARS-CoV-2 spike proteins have recently
determined distinct functional states of the B. 1.1. 7 and B. 1.351 spike variants, providing a …
determined distinct functional states of the B. 1.1. 7 and B. 1.351 spike variants, providing a …
[HTML][HTML] Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: allosteric communications between and within viral …
The interaction between the Spike (S) protein of SARS-CoV-2 and the human angiotensin
converting enzyme 2 (hACE2) is essential for infection, and is a target for neutralizing …
converting enzyme 2 (hACE2) is essential for infection, and is a target for neutralizing …