Oxidative stress, a condition characterized by an imbalance between pro-oxidant molecules
and antioxidant defense systems, is increasingly recognized as a key contributor to cancer …

Vitamin C has been known for decades. It is common in everyday use as an element of the
diet, supplementation, and a preservative. For years, research has been conducted to …

Reactive oxygen species (ROS) produced either endogenously or exogenously can attack
lipid, protein and nucleic acid simultaneously in the living cells. In nuclear and mitochondrial …

Vitamin C readily scavenges reactive oxygen and nitrogen species and may thereby prevent
oxidative damage to important biological macromolecules such as DNA, lipids, and proteins …

Aldehydes are organic compounds that are widespread in nature. They can be formed
endogenously by lipid peroxidation (LPO), carbohydrate or metabolism ascorbate …

The vitamins are a chemically disparate group of compounds whose only common feature is
that they are dietary essentials that are required in small amounts for the normal functioning …

Vitamin C (or ascorbic acid) is regarded as the most important water-soluble antioxidant in
human plasma and mammalian cells which have mechanisms to recycle and accumulate it …

Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide
variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the …

Oxidative stress induces adaptations in the expression of protective enzymes and heat
shock proteins (HSPs) in a variety of tissues. We have examined the possibility that …

The earliest work on oxidation of a biologically important protein was on the effects of
selected radicals generated by radiolysis on the enzyme, lysozyme (Adams et al., 1969) …