MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

X Wang, Y He, B Mackowiak, B Gao - Gut, 2021 - gut.bmj.com
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene
expression by binding to specific mRNA targets and promoting their degradation and/or …

Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets

M Klingenberg, A Matsuda, S Diederichs, T Patel - Journal of hepatology, 2017 - Elsevier
The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

MicroRNAs in liver disease

G Szabo, S Bala - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

S Hsu, B Wang, J Kota, J Yu… - The Journal of …, 2012 - Am Soc Clin Investig
miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism
and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in …

[HTML][HTML] Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis

YA Ghouri, I Mian, JH Rowe - Journal of carcinogenesis, 2017 - ncbi.nlm.nih.gov
Since the 1970s, the epidemic of hepatocellular carcinoma (HCC) has spread beyond the
Eastern Asian predominance and has been increasing in Northern hemisphere, especially …

Molecular and functional roles of microRNAs in the progression of hepatocellular carcinoma—a review

K Oura, A Morishita, T Masaki - International Journal of Molecular …, 2020 - mdpi.com
Liver cancer is the fourth leading cause of cancer deaths globally, of which hepatocellular
carcinoma (HCC) is the major subtype. Viral hepatitis B and C infections, alcohol abuse, and …

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer

C Braconi, T Kogure, N Valeri, N Huang, G Nuovo… - Oncogene, 2011 - nature.com
The human genome is replete with long non-coding RNAs (lncRNA), many of which are
transcribed and likely to have a functional role. Microarray analysis of> 23 000 lncRNAs …

Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma

J Hou, L Lin, W Zhou, Z Wang, G Ding, Q Dong, L Qin… - Cancer cell, 2011 - cell.com
The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to
be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and …

MicroRNAs in NF-κB signaling

X Ma, LE Becker Buscaglia… - Journal of molecular cell …, 2011 - academic.oup.com
Nuclear factor κB (NF-κB) is a transcriptional factor that regulates a battery of genes that are
critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor …